2 edition of Spindle dynamics and chromosome movements found in the catalog.
Spindle dynamics and chromosome movements
Andrew S. Bajer
|Statement||[by] Andrew S. Bajer and J. Molè-Bajer.|
|Series||International review of cytology. Supplements -- 3|
Besides chromosome separation and spindle disassembly, many other events occur at or subsequent to anaphase onset, including the movement of chromosomes and spindle poles, the elongation of polar microtubules, the formation of interzonal microtubule bundles, the relocation of motor and nonmotor spindle proteins, and the reorganization of cortical actin and myosin filaments for cytokinesis. will review the spindle dynamics that align and segregate chromosomes advantage might have been to obviate the book-keeping involved in chromosome movement are needed to fully assess and.
The centromere proximal spot began anaphase A chromosome movement toward the spindle pole body at an average spindle length of ± μm (Table IV; n = 15). Regression lines were drawn through each plot of centromere proximal chromosome spot movement to the spindle . spindle dynamics that is essential for mitotic progression. DDA3 depletion results in a high frequency of unaligned chromosomes, a substantial reduction in tension across sister kinetochores at metaphase, and a decrease in the velocity of chromosome segregation at anaphase. DDA3 associates with the mitotic spindle and controls microtubule.
To better understand the role of kinesin-8 proteins in mitosis, we studied the effects of deletion of the fission yeast kinesin-8 proteins Klp5 and Klp6 on chromosome movements and spindle length dynamics. Aberrant microtubule-driven kinetochore pushing movements and tripolar mitotic spindles occurred in cells lacking Klp5 but not Klp6. Kinetochore and spindle in chromosome movement Kinetochore, which is coincident with the centromere and is a trilaminar plate situated at the primary constriction (or centromere) of the chromosome, plays an important role in chromosome movements.
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Spindle dynamics and chromosome movements. New York, Academic Press, (OCoLC) Material Type: Internet resource: Document Type: Book, Internet Resource: All Authors / Contributors: Andrew S Bajer; J Molè-Bajer.
This review of current knowledge is divided into 8 chapters: (1) Introduction; (2) Microtubules; (3) The course of mitosis; (4) Kinetochores and spindle fibers; (5) Spindle shape and role of asters in chromosome movements; (6) Chromosome interaction in mitosis and meiosis; (7) Hypotheses of chromosome movements and spindle structure; (8) Features of general model of chromosome movements Cited by: Bajer AS and Mole-Bajer J () Spindle dynamics and chromosome movements.
Int Rev Cytol Suppl 3: 1– Google Scholar Coue M, Lombillo VA and Mcintosh JR () Microtubule depolymerization promotes particle and chromosome Spindle dynamics and chromosome movements book in by: Journals & Books; Register Sign in.
Vol Issues 5–6, AugustPages Calcium, spindle microtubule dynamics and chromosome movement Keywords. mitosis. microtubules. mitotic spindle. calcium. chromosome movement. Recommended articles Citing articles (0). Abstract.
Dynamic turnover of the spindle is a driving force for chromosome congression and segregation in mitosis. Through a functional genomic analysis, we identify DDA3 as a previously unknown regulator of spindle dynamics that is essential for mitotic progression.
DDA3 depletion results in a high frequency of unaligned chromosomes, a substantial reduction in tension across sister kinetochores at metaphase, and a decrease in the velocity of chromosome segregation Cited by: To identify novel regulators of spindle dynamics and chromosome movement, we undertook a genomic analysis to identify candidate mitotic genes based on their expression profiles (Wong and Fang, ; Zhao et al., ; Seki and Fang, ).Subsequent functional analysis of these genes in a targeted siRNA screen identified DDA3 as a regulator of the mitotic spindle.
Mitotic Spindle Dynamics and Chromosome Movement During Anaphase. Anaphase is dominated by the orderly movement of sister chromatids to opposite spindle poles brought about by the combined action of motor proteins and changes in microtubule length.
There are two components to anaphase chromosome movements (Fig. Mitosis is the process that partitions newly replicated chromosomes equally into separate parts of a cell.
The last step in the cell cycle, mitosis takes about 1 hour in an actively dividing animal cell. During that period, the cell builds and then disassembles a specialized microtubule structure, the mitotic apparatus. Larger than the nucleus, the mitotic apparatus is designed to attach and.
Anaphase chromosome movement is complemented by Pac-Man, the shortening of the k-fiber at its chromosomal interface. Thus, Drosophila spermatocytes share the sites of spindle dynamism and mechanisms of chromosome movement with mitotic cells.
The data reveal the applicability of the photobleaching assay for measuring MT dynamics in primary cultures. To determine whether spindle pole organization is required for chromosome movement in mitosis, we monitored chromosome dynamics in cultured human CFPAC-1 cells by time-lapse DIC microscopy.
Uninjected control cells and cells injected with a nonimmune IgG progressed from the prophase/prometaphase transition (as judged by nuclear envelope. Mechanical forces direct spindle assembly, 18 chromosome movement, 19,20 stabilization of microtubules, 21 and correction of errors in spindle assembly and chromosome attachment to microtubules.
22 They also regulate anaphase onset. 23 These forces are generated by various molecular processes, which include ATPase motors, microtubule. Force, work and energy underlying chromosome motility in the mitotic spindle.
In the sub-cellular regime, low Reynolds number conditions dominate motility (i.e. Re movements, and viscous forces (due to friction) have the major effect [4, 5].For example, in Drosophila syncytial embryo spindles, anaphase A lasts.
Mitotic Spindle Dynamics and Chromosome Movement During Anaphase Anaphase is dominated by the orderly movement of sister chromatids to opposite spindle poles brought about by the combined action of motor proteins and changes in microtubule length. There are two components to anaphase chromosome movements (Fig.
We discuss the structures and molecular kinetics of kinesin-8 motors. We highlight the essential roles and mechanisms of kinesin-8 in the regulation of microtubule dynamics and spindle organization. We also shed light on the functions of kinesin-8 motors in chromosome movement and the spindle assembly checkpoint during the cell cycle.
Microtubule-associated proteins and spindle dynamics. The dynamic lengthening and shortening of spindle microtubules, through a process known as dynamic instability determines to a large extent the shape of the mitotic spindle and promotes the proper alignment of chromosomes at the spindle.
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Source: Samelius, L. and Wagberg, E. () idem: Mitotic Spindle Spindle Pole Spindle Microtubule Spindle Fiber Chromosome Movement These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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